PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.

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Date
2018-10-14
Author
Ruiz Noa, Yeniley
Hernandez Bello, Jorge
Llamas Covarrubias, Mara Anais
Palafox Sanchez, Claudia Azucena
Oregon Romero, Edith
Sánchez Hernández, Pedro Ernesto
Ramirez Dueñas, Maria Guadalupe
Parra Rojas, Isela
Muñoz Valle, Jose Francisco
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Abstract
Background: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40 CD154 interaction promotes pro¿inflammatory cytokines secretion and autoantibodies production. PTPN22 gene encodes LYP protein, an inhibitor of T¿ and B¿cell activation. PTPN22 1858C>T polymorphism confers rheumatoid arthritis (RA) susceptibility. Hence, we evaluate the relationship between 1858C>T polymorphism with CD40 and CD154 expression and IFN secretion in RA patients.
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http://ri.uagro.mx/handle/uagro/1186
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http://creativecommons.org/licenses/by-nc-nd/4.0
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0