Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells.

Abstract

Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic agent in cervical cancer and induces genetic instability, including disruption of microRNA gene expression. In the present study, we analyzed the underlying mechanism of how AP¿1 transcription factor can active miR-21 gene expression in cervical cancer cells.