Polimorfismos +1444 c/t y +1846 g/a del gen de la proteína C reactiva y su asociación con los niveles de su proteína en personas con obesidad

Abstract

Several single nucleotide polymorphisms (SNPs) in the C reactive protein gene (CRP) have been associated with increase serum concentration of their protein, some of them have been correlated with cardiovascular disease. In this study we determined the association between genotypes-haplotypes of the SNPs +1444 C/T and +1846 G/A with the serum concentration of CRP and other cardiovascular risk factors. Were studied 100 healthy subjects and 101 with obesity from Guerrero state, of both genders, 30 years or older, normotensive, without acute or chronic diseases, were analyzed the demographic, somatometric characteristics and various biochemical parameters of clinical laboratory of each participant and the identification of the polymorphisms +1444 C/T and +1846 G/A, was performed by PCR-RFLP