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dc.contributorLeyva Vázquez, Marco Antonio
dc.contributor.advisorLeyva Vázquez, Marco Antonio; 264272
dc.contributor.authorOrganista Nava, Jorge
dc.creatorOrganista Nava, Jorge; 236745
dc.date.accessioned2019-03-28T00:38:19Z
dc.date.available2019-03-28T00:38:19Z
dc.date.issued2009-08
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/210
dc.description.abstractThis study evaluated the association of -401C/T and +452C/T polymorphisms of y-glutamyl hydrolase and the lack of response to methotrexate in acute lymphoblastic leukemia. Genotyping was performed 70 children with acute lymphoblastic leukemia and 140 without. Association between -401C/T polymorphism and lack of response was found (p=0.028), patients with -401T/T genotype have 10.83 (CI95 1.30-90.14) more chance for a relapse of leukemia. No association was found between the +452C/T polymorphism and the response. Therefore, our investigation suggests that the -401C/T polymorphism in the y-glutamyl hydrolase may be a factor that would generate this lack of response to methotrexate in patients with ALL while the +452C/T cannot
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología (CONACyT) de México
dc.formatpdf
dc.language.isoeng
dc.publisherUniversidad Autónoma de Guerrero (México)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4
dc.subjectTesauro National Library of Medicine /leukemia
dc.subjectTesauro National Library of Medicine /Glutamyl
dc.subjectTesauro National Library of Medicine /Hydrolase
dc.subjectTesauro National Library of Medicine /nucleotide
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD
dc.titlePolimorfismos en el gen de la y-glutamil hidrolasa y respuesta al metotrexato en leucemia linfoblástica aguda en México
dc.typeTesis de maestría
dc.contributor.committeeMemberReyes Maldonado, Elba
dc.type.conacytmasterThesis
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelMaestría
dc.thesis.degreenameMaestría en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro07286017
dc.viewer.xmlhttp://ri.uagro.mx:8081/viewer/index.php?code=07286017


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