Efecto de miR-24 sobre YKL-40 en leucemia linfoblástica aguda.
Resumen
YKL-40 also known as CHI3L1 (Chitinase-3-like protein 1), is an inflammatory glycoprotein which is secreted by different cell types such as inflammatory cells. This protein is elevated in the serum or plasma of patients with different types of cancer and high concentration of this protein is associated with poor prognosis and short survival in patients with liver, breast, lung, bladder, and endometrial cancers. In Mexico, acute lymphoblastic leukemia (ALL) is the most common type of cancer that affects the pediatric population. The prognosis of patients with ALL is difficult to establish. Hence, the objective of this study was to analyze the plasma levels of YKL-40 in Mexican children with ALL and investigated its role as a prognostic factor. We performed a case-control study in a population of 90 children aged 1 to 18 years, among whom 45 had ALL and 45 were hematologically healthy. YKL-40 levels in the subjects¿ plasma samples were measured using an ELISA kit. We found that the plasma levels of YKL-40 were significantly higher in children with ALL than in controls (p<0.0001). Children with ALL who had high plasma levels of YKL-40 (¿36.34 ng/mL) had shorter survival durations than those with low levels (<36.34 ng /mL) (p<0.05).Our investigation revealed that the YKL-40 plasma level, age/initial leukocyte count, and Central nervous system (CNS) invasion are associated with the prognosis of children with ALL (OR= 6.06, 95%IC = 1.1-31.6, p = 0.03; OR= 8.53, 95%IC= 1.2-58.2, p= 0.03 and OR= 6.45, 95%IC= 1.01-41.2, p= 0.04). YKL-40 plasma levels could therefore be used as a prognostic biomarker in children with ALL; however, more studies are required to confirm the role of this protein in patients with this disease.
Resumen
En México el cáncer es un problema de salud pública, afectando a adultos y a población infantil. En el estado de Guerrero la leucemia linfoblástica aguda (LLA), es el tipo de cáncer más común que afecta a población menor de 18 años de edad. El pronóstico de un paciente con LLA, es difícil de establecer, se han planteado diversos factores que pueden influir en el pronóstico de un paciente con LLA, algunos de ellos son; la edad, alteraciones citogenéticas como las translocaciones, el sexo conteo inicial de leucocitos e invasión al sistema nervioso central (SNC). La búsqueda de nuevos biomarcadores pronósticos es importante y debe ser progresiva. Existen varios estudios que proponen a la proteína YKL-40 como biomarcador de supervivencia en diferentes tipos de cáncer, (pulmón, mama, hígado, vejiga y endometrio) ya que niveles elevados de esta proteína en suero o plasma se han relacionado con corta supervivencia y mal pronóstico. Se ha propuesto que miR-24 puede regular a YKL-40. Mir-24 es un microRNA asociado a la tumorigénesis y ha sido considerado un oncomiR, se ha estudiado en diferentes tipos de cáncer como en cáncer de mama, gástrico, páncreas y pulmón.
Colecciones
- Tesis [85]