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dc.contributorParra Rojas, Isela
dc.contributor.advisorPARRA ROJAS, ISELA; 39755
dc.contributor.authorTepec Casarrubias, Brenda
dc.date.accessioned2023-10-31T17:04:50Z
dc.date.available2023-10-31T17:04:50Z
dc.date.issued2021-01
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/4148
dc.description.abstractBackground: Insulin resistance (IR) is a pathophysiological state in which there is a reduced capacity of insulin-sensitive tissues to respond to the action of this hormone. IR plays an important role in the alteration of lipid metabolism and the HDL and LDL lipoprotein subclasses, resulting in a proatherogenic phenotype. Objective: To evaluate the relationship between clinical and metabolic markers with the serum levels of Ox-HDL, Ox-LDL and sdLDL in people with and without IR. Methodology: 160 participants of both sexes, from the state of Guerrero, with ages between 18 and 30 years, were included, divided into two groups: 80 young people without IR and 80 with IR. The lipid profile, glucose and uric acid were quantified by colorimetric enzymatic methods. An enzyme-linked immunosorbent assay (ELISA) was performed to quantify the concentration of insulin, Ox-HDL, Ox-LDL, and sdLDL. Results: The group with IR presented higher body adiposity, BMI, waist-hip ratio, SBP, DBP, increase in serum glucose, insulin, cholesterol, TG and LDL-C, compared to those without IR (p <0.05). 63% of the men with IR presented obesity and a higher concentration of cholesterol, TG, LDL-c and uric acid compared to women with IR (p <0.001). The Ox-LDL concentration was higher in women with IR compared with insulin-resistant men (p <0.001). The sdLDL concentration increased in men with IR compared to women (p = 0.001). Women with IR have an 18 times greater risk of presenting Ox-LDL concentrations in the third tertile (p <0.001). Men with IR have a 6 times greater risk of presenting levels of sdLDL in the third tertile compared to women with IR (p = 0.005). Women with uric acid levels in the second tertile have higher serum Ox-LDL levels. In men, the sdLDL concentration was higher when uric acid levels were in the first tertile (p = 0.02). Conclusion: Gender is associated with the increase in serum concentrations of Ox-LDL and sdLDL in the presence of IR.
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología
dc.formatpdf
dc.language.isospa
dc.publisherUniversidad Autónoma de Guerrero (México)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectinsulin resistance
dc.subjectlipoproteins
dc.subjectoxidation
dc.subjecturic acid
dc.subjectdyslipidemia
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::BIOLOGÍA HUMANA::LÍPIDOS
dc.titleIdentificación de alteraciones en las lipoproteínas HDL y LDL en personas con resistencia a la insulina.
dc.typeTesis de maestría
dc.contributor.committeeMemberLara Riegos, Julio César
dc.type.conacytmasterThesis
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||2410||230218
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelMaestría
dc.thesis.degreenameMaestría en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro10080954


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