Efecto de la sobre-expresión de DNMT3B en la actividad transcripcional de genes relacionados con el cáncer

Abstract

Abnormal methylation of promoters of genes suppressors of tumor and repairers of DNA is an epigenetic process that leads to its transcriptional silencing and is also a common event observed in cancer. DNMT3B is a DNA methyltransferase that is overexpressed in several types of cancer and primary tumors and it is responsible for the abnormal methylation of cancer-related genes. Although 5 genes are known as targets of DNMT3B, the elements that explain site-specific methylation are currently in the process of being explained