Participación de la progesterona en la secreción y expresión de la MMP-2 y la MMP-9, y su papel en la activación de los factores de transcripción AP-1 y NF-kB en líneas celulares de cáncer de mama

Abstract

Progesterone is a steroid hormone that regulates the development of normal mammary gland. However, there is evidence indicating that this hormone is implicated in the growth of breast tumors. Little is know about the role of progesterone on the secretion of molecules involved in cell migration such as MMP-2 and MMP-9 and on the activation transcription factors that regulate survival and proliferation such as AP-1 and NF-kB. Here, we demonstrated that stimulation of MCF-7 cells with progesterone promotes the secretion of MMP-9