Genotipos s y m del gen vacA de Helicobacter pylori en pacientes con patología gastroduodenal

Abstract

Helicobacter pylori is the most common cause of gastritis and it is also associated to a high incidence of gastroduodenal ulcer. VacA cytotoxin is the major virulence marker associated with H. pylori pathogenicity. VacA induces the formation of intracellular vacuoles in the cell lines, modification of cellular metabolism, depend on the vacA genotype of the infecting strain. The strains s1m1 and s1m2 damage the gastric epithelium, while those s2m1 and s2m2 cause little or no damage