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DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

dc.contributor.authorPeralta Arrieta, Irlanda
dc.contributor.authorHernández Sotelo, Daniel
dc.contributor.authorCastro Coronel, Yaneth
dc.contributor.authorLeyva Vazquez, Marco Antonio
dc.contributor.authorIllades_Aguiar, Berenice
dc.creatorPeralta Arrieta, Irlanda; 368293
dc.creatorHernández Sotelo, Daniel; 259435
dc.creatorCastro Coronel, Yaneth; 208090
dc.creatorLeyva Vazquez, Marco Antonio; 264272
dc.creatorIllades_Aguiar, Berenice;#0000-0003-3937-335X
dc.date.accessioned2019-04-04T00:02:02Z
dc.date.available2019-04-04T00:02:02Z
dc.date.issued2017-01
dc.identifier.issn2156-6976
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/405
dc.description.abstractAltered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B. We found that the overexpression of DNMT3B in HaCaT cells, modulate the expression of genes related to cancer, downregulated the expression of 151 genes with CpG islands and downregulated the expression of the VAV3 gene via methylation of its promoter. These results highlight the importance of DNMT3B in gene expression and human cancer
dc.formatpdf
dc.language.isoeng
dc.publisherAmerican Journal of Cancer Research
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4
dc.subjectCAB Thesaurus /Methylation
dc.subjectCAB Thesaurus /De novo methyltransferase
dc.subjectCAB Thesaurus /Overexpression of DNMT3B
dc.subjectCAB Thesaurus /Cancer
dc.subjectCAB Thesaurus /Cancer-related genes
dc.subjectCAB Thesaurus /CpG island
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::PATOLOGÍA::CARCINOGÉNESIS
dc.titleDNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||3207||320703
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro05091616


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