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Efecto de la disminución de HOTAIR en la hidroximetilación global en la línea celular HeLa.
(Universidad Autónoma de Guerrero (México), 2019-01)
Genetic and epigenetic alterations lead to the initiation and development of cancer. Epigenome of cancer cell is characterized by aberrant methylation of tumor suppressor genes, the functional consequence is the transcriptional ...
Efecto de HOTAIR sobre TET1 y la vía WNT en la línea celular HeLa.
(Universidad Autónoma de Guerrero (México), 2020-01)
Hox transcript antisense intergenic RNA (HOTAIR) es un RNA no codificante largo (lncRNA) que se transcribe de la región 12q13.13, específicamente de la cadena antisentido en la región intergénica entre HOXC11 y HOXC12, y ...
HOTAIR Knockdown Decreased the Activity Wnt/ß-Catenin Signaling Pathway and Increased the mRNA Levels of Its Negative Regulators in Hela Cells
(Cellular Physiology and Biochemistry, 2019-12-05)
Background/Aims: HOTAIR is a long non-coding RNA that promotes the development of human cancer. TET1 enzyme is involved in DNA demethylation by oxidation of 5-methylcytocine and it is considered a tumor suppressor in some ...