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Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells
(BioMed Central, 2016-03-14)
Background: Expression of the microRNA miR-21 has been found to be altered in almost all types of cancers and it has been classified as an oncogenic microRNA or oncomir. Due to the critical functions of its target proteins ...
vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
(Medical Microbiology, 2017-11-30)
Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is ...
Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico.
(Medicine, 2019-12)
The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development. Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) ...
Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)
(2014-03-13)
Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect gene expression. The progression from precursor lesions to invasive cervical cancer is influenced by persistent human papilloma virus ...
Diversidad de los genotipos vacA y cagA de helicobacter pylori y expresión de interferón gamma en pacientes con gastritis crónica y cáncer gástrico
(Revista de Gastroenterología de México, 2014-11-26)
Background: Helicobacter pylori (H. pylori) is the main risk factor for the development of chronic gastritis, gastric ulcer, and gastric cancer. In H. pylori-infected individuals, the clinical result is dependent on various ...
miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer
(Infectious Agents and Cancer, 2015-01)
The aberrant expression of miR-23b is involved in the development and progression of cancer. The aim of this study was to evaluate the potential role of methylation in the silencing of miR-23b in cervical cancer celllines ...
CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
(Gut Pathogens, 2019-02-13)
Helicobacter pylori is a Gram¿negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4¿secretion system ...