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A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile
(International Journal of Immunopathology and Pharmacology, 2020-12-21)
The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (RORC) mRNA expression in psoriatic ...
Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells
(BioMed Central, 2016-03-14)
Background: Expression of the microRNA miR-21 has been found to be altered in almost all types of cancers and it has been classified as an oncogenic microRNA or oncomir. Due to the critical functions of its target proteins ...
Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects
(BioMed Central, 2015-09-13)
Background: Diet is an important environmental factor that interacts with genes to modulate the likelihood of developing disorders in lipid metabolism and the relationship between diet and genes in the presence of other ...
vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
(Medical Microbiology, 2017-11-30)
Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is ...
La leptina promueve la expresión de Hic-5 y la formación de puntos de actina por la vía dependiente de FAK-Src en células epiteliales mamarias MCF10A.
(Biomédica, 2019-01-01)
Leptin is a hormone secreted by adipocytes that has been associated with the epithelial-mesenchymal transition (EMT). Additionally, leptin promotes the migration and invasion of mammary epithelial cells through the activation ...
KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico.
(Hindawi, 2019-01-06)
Systemic Sclerosis (SSc) is an autoimmune, inflammatory, and multisystemic disease characterized by the presence of autoantibodies and fibrosis. The pathogenesis involves the interaction between immune system cells such ...
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
(ELSEVIER, 2019-05)
Polymorphisms in folate-related genes are closely related to the development of cancer. The 5,10-MTHFR 677C>T and RFC1 80G>A polymorphisms are associated with an increased risk of susceptibility to pediatric ALL.
Terminal Deoxynucleotidyl Transferase in type B Acute Lymphoblastic Leukemia.
(Avens Publishing, 2019-02)
Terminal deoxynucleotidyl transferase (TdT or DNTT) is a nuclear enzyme whose expression is restricted to normal tissue (thymus and bone marrow) and to lymphoid precursors of the B and T cell. TdT catalyzes the addition ...
New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.
(FebsPress, 2019-04-18)
Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators of gene expression that control oncogenic pathways to modulate the radiotherapy ...
Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells.
(Cancer Cell International, 2019-01)
Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic agent in ...