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dc.contributor.authorRoman Roman, Adolfo
dc.contributor.authorMartinez Santos, Veronica Iranzu
dc.contributor.authorCastañon Sanchez, Carlos Alberto
dc.contributor.authorAlbañil Muñoz, Alan J
dc.contributor.authorGonzález Mendoza, Paola
dc.contributor.authorSoto¿Flores, Diana G
dc.contributor.authorMartinez Carrillo, Dinorah Nashely
dc.contributor.authorFernandez Tilapa, Gloria
dc.creatorROMAN ROMAN, ADOLFO; 274958
dc.creatorMARTINEZ SANTOS, VERONICA IRANZU; 166620
dc.creatorCASTAÑON SANCHEZ, CARLOS ALBERTO; 101865
dc.creatorMARTINEZ CARRILLO, DINORAH NASHELY; 210671
dc.creatorFernandez Tilapa, Gloria;#0000-0002-3737-2399
dc.date.accessioned2020-04-21T02:28:38Z
dc.date.available2020-04-21T02:28:38Z
dc.date.issued2019-02-13
dc.identifier.issn1757-4749
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/1214
dc.description.abstractHelicobacter pylori is a Gram¿negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4¿secretion system (T4SS) and the cytotoxin CagA. Translocation of CagA through the T4SS triggers host¿signaling pathways. One of the T4SS proteins is CagL, which is necessary for CagA translocation. CagL is a 26¿kDa protein that contains a hypervariable motif, which spans residues 58 to 62. Several polymorphisms in this region have been associated with different disease outcomes, e.g. in Mexico, N58 is associated with a higher risk of gastric cancer. The aim of this work is to analyze the sequence of the hypervariable motif (residues 58 to 62) of clinical isolates from Mexican patients with chronic gastritis, and to correlate these polymorphisms with the vacA genotype.
dc.formatpdf
dc.language.isospa
dc.publisherGut Pathogens
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectChronic gastritis
dc.subjectpolymorphisms
dc.subjectPolymorphic
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
dc.titleCagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||3299
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro6211


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