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Polimorfismos en el gen PON1 y daño al DNA en población expuesta ocupacionalmente a plaguicidas organofosforados
(Universidad Autónoma de Guerrero (México), 2014-06)
PON1 is an enzyme that hydrolyzes the active metabolites of OP (oxons). It has determined that single nucleotide polymorphisms (SNP) in the promoter (108CT) and coding (L55M and Q192R) region of PON1 gene induce variations ...
Regulación de la expresión del receptor NMDA por el resveratrol en isquemia cerebral in vivo
(Universidad Autónoma de Guerrero (México), 2013-10)
Neuronal loss during cerebral ischemia can be prevented by modulating the celular redox state. It has been suggested that regulation of N-methyl-D-aspartate receptor subunits by antioxidants decrease glutamate excitotoxicity. ...
Polimorfismo -149C>T, expresión de la DNA metiltransferasa 3B y metilación de los promotores de los genes FHIT y MGMT en la carcinogénesis cervical
(Universidad Autónoma de Guerrero (México), 2010-12)
Infection with human papilloma virus (HPV) is necessary in the development of cervical cancer (CC), but clearly other factors that favor progression, and epigenetic alterations. Among them is DNA methylation is catalyzed ...
Papel de Src sobre marcadores clásicos de la transición epitelio-mesenquimal en células epiteliales mamarias estimuladas con leptina
(Universidad Autónoma de Guerrero (México), 2017-12)
Background: Several studies demonstrate an association between obesity and breast cancer (BC). Leptin is a hormone secreted by adipocytes which increases during obesity. Experimental evidence shown that leptin may promote ...
Efecto de la infección por Gardnerella vaginalis sobre la respuesta inmune innata en lesión escamosa intraepitelial de cérvix uterino y la línea celular HeLa
(Universidad Autónoma de Guerrero (México), 2018-11)
Bacterial vaginosis (BV) is a polymicrobial clinical entity characterized by the lack of inflammatory cells. However, in cervicovaginal fluids of women with BV, alterations in inflammatory cytokine levels have been reported ...
Modulación de la proliferación y supervivencia celular por la oncoproteína E6 de la variante E-G350 del VPH-16 en células HaCaT en respuesta a quimioterapia y radioterapia
(Universidad Autónoma de Guerrero (México), 2015-01)
E6 oncoprotein of HPV-16 alters cell proliferation, apoptosis, and the transcriptional regulation of several genes by binding to cellular proteins as E6AP, p53, Bax and caspase-8. Have been reported to E6 can bind and ...
Polimorfismos en los genes de adiponectina (RS1501299) y de su receptor 2 (RS767870) asociados al síndrome metabólico
(Universidad Autónoma de Guerrero (México), 2012-11)
Background: Adiponectin stimulates fatty acid oxidation, reduces triglycerides, improves glucose metabolism and exerts a protective effect on blood vessels due to its effect anti-inflammatory and anti-atherogenic. Variation ...
Efecto del resveratrol sobre el nivel de expresión de los transportadores de glucosa GLUT en isquemia cerebral in vivo
(Universidad Autónoma de Guerrero (México), 2014-01)
Ischemic stroke results from occlusion of a major cerebral artery and involves a cascade of metabolic events that begin during insult and proceed well into the blood flow recovery period [reperfusion (R)]. Impairment of ...
Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
(Universidad Autónoma de Guerrero (México), 2019-01)
In Mexico, invasive cervical carcinoma (ICC) remains the second most frequent carcinoma in women [1]. Persistent High-Risk HPV infection (HR-HPV) is the main risk factor for cervical carcinogenesis [2]. The viral infection ...
Expresión de p53, p21Waf1/Cip1 y E6 y el estado físico del ADN del VPH16 en lesiones tempranas del cérvix uterino
(Universidad Autónoma de Guerrero (México), 2013-10)
The aim of this study was to determine the correlation between expression of HPV16 E6, p53 and p21 proteins and the physical state of HPV16 in cervical cytologies without squamous intraepithelial lesions (Non-SIL) and with ...