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dc.contributorAlarcón Romero, Luz Del Carmen
dc.contributor.advisorAlarcón Romero, Luz del Carmen; 259901
dc.contributor.authorCastro Mora, Wendy Aide
dc.creatorCastro Mora, Wendy Aide; 778715
dc.descriptionThe persistent infection of HPV16 and its DNA integration increase the risk of precancerous lesions progression to invasive cervical carcinoma (ICC) due to viral oncoproteins E6 and E7 overexpression, which are determinants for the malignant phenotype. Nevertheless, not all Low-Squamous Intraepitelial Lesions (LSIL) showing viral DNA integration are able to progress to High-Squamous Intraepitelial Lesions (HSIL) or carcinomes, indicating other factors are necessary for cell transformation
dc.description.abstractIn Mexico, invasive cervical carcinoma (ICC) remains the second most frequent carcinoma in women [1]. Persistent High-Risk HPV infection (HR-HPV) is the main risk factor for cervical carcinogenesis [2]. The viral infection is characterized cytologically by the presence of coilocytes that includes karyomegaly, binucleation, perinuclear halo and hyperchromasia among other cytological alterations. Bethesda cytological nomenclature uses these characteristics to classify pre-cancerosus lesions as lowgrade squamous intraepithelial lesion (LSIL) and high-grade (HSIL)
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología (CONACYT)
dc.publisherUniversidad Autónoma de Guerrero (México)
dc.subjectTesauro Descriptores en Ciencias de la Salud /Viral integration
dc.subjectTesauro Descriptores en Ciencias de la Salud /Human Papilloma Virus
dc.subject.classificationBIOLOGÍA Y QUÍMICA::QUÍMICA
dc.titleExpresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
dc.typeTesis de maestría
dc.contributor.committeeMemberOrtuño Pineda, Carlos
dc.contributor.committeeMemberFlores Alfaro, Eugenia
dc.contributor.committeeMemberVences Velázquez, Amalia
dc.contributor.committeeMemberGuzmán Guzmán, Iris Paola
dc.contributor.committeeMemberPereira Suarez, Ana Laura
dc.format.digitalOriginBorn digital
dc.thesis.degreenameMaestría en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineBiología y Química

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