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dc.contributorGuzman Guzman, Iris Paola
dc.contributor.advisorGUZMAN GUZMAN, IRIS PAOLA; 210828
dc.contributor.authorRamírez Vélez, Claudia Isabel
dc.creatorRamírez Vélez, Claudia Isabel; 923221
dc.date.accessioned2023-10-26T01:56:07Z
dc.date.available2023-10-26T01:56:07Z
dc.date.issued2020-12
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/4132
dc.description.abstractRheumatoid arthritis (RA) is a progressive autoimmune disease characterized by inflammation, pain, and joint limitation. The citrullination is a process mediated by peptidyl arginine deiminase (PADI) enzymes and is recognized as the main trigger for RA`s autoimmunity. The levels of PADI2 have been correlated with elevated clinical activity and anti-CCP levels in RA. Polymorphisms in the PADI2 gene could be associated with the citrullination level, the serological pattern, and RA`s pathological process. This study`s objective was to evaluate the association between the rs2235926, rs2057094 and rs1005753 polymorphisms in the PADI2 gene with RA`s clinical variability in patients from southern Mexico. Methods: A cross-sectional study was carried out. The rs2057094, rs2235926 and rs1005753 polymorphisms of the PADI2 gene were genotyped by TaqMan real-time PCR assay. A rheumatology specialist evaluated the patient`s clinical characteristic and autoantibodies levels (rheumatoid factor, anti-CCP and anti-vimentin) were determined by immunonephelometry and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using STATA version 14 software and haplotype estimation in the SHEsis program. Results: Allele T carriers of rs2235926, rs2057094 and rs1005753 in the PADI2 gene, present higher levels of ACPA and RF, compared to non-carriers. The TT genotype of rs22355926 is related to high levels of RF (p = 0.03). Carriages of the TTT haplotype had an increased risk to present high radiological index (p = 0.001). Conclusion: The polymorphisms and haplotypes in the PADI2 gene are associated to serological characteristics and predictive markers of progression in RA patients from southern Mexico.
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología
dc.formatpdf
dc.language.isospa
dc.publisherUniversidad Autónoma de Guerrero (México)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectRheumatoid arthritis
dc.subjectpolymorphisms
dc.subjectPADI2
dc.subjectantibodies
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::CIENCIAS CLÍNICAS::GENÉTICA CLÍNICA
dc.titlePolimorfismos y haplotipos en el gen PADI2 y su relación con la diversificación clínica en pacientes con artritis reumatoide del sur de México.
dc.typeTesis de maestría
dc.contributor.committeeMemberFalfán Valencia, Ramcés
dc.contributor.committeeMemberParra Rojas, Isela
dc.type.conacytmasterThesis
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||3201||320102
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelMaestría
dc.thesis.degreenameMaestría en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro9099720


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