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La leptina promueve la expresión de Hic-5 y la formación de puntos de actina por la vía dependiente de FAK-Src en células epiteliales mamarias MCF10A.
(Biomédica, 2019-01-01)
Leptin is a hormone secreted by adipocytes that has been associated with the epithelial-mesenchymal transition (EMT). Additionally, leptin promotes the migration and invasion of mammary epithelial cells through the activation ...
KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico.
(Hindawi, 2019-01-06)
Systemic Sclerosis (SSc) is an autoimmune, inflammatory, and multisystemic disease characterized by the presence of autoantibodies and fibrosis. The pathogenesis involves the interaction between immune system cells such ...
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
(ELSEVIER, 2019-05)
Polymorphisms in folate-related genes are closely related to the development of cancer. The 5,10-MTHFR 677C>T and RFC1 80G>A polymorphisms are associated with an increased risk of susceptibility to pediatric ALL.
Terminal Deoxynucleotidyl Transferase in type B Acute Lymphoblastic Leukemia.
(Avens Publishing, 2019-02)
Terminal deoxynucleotidyl transferase (TdT or DNTT) is a nuclear enzyme whose expression is restricted to normal tissue (thymus and bone marrow) and to lymphoid precursors of the B and T cell. TdT catalyzes the addition ...
New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.
(FebsPress, 2019-04-18)
Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators of gene expression that control oncogenic pathways to modulate the radiotherapy ...
Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells.
(Cancer Cell International, 2019-01)
Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic agent in ...
Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients.
(2019-11-06)
Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional ...
Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico.
(Medicine, 2019-12)
The chronic inflammation and damage to the gastric epithelium induced by Helicobacter pylori (H. pylori) are the main risk factors for gastric cancer development. Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) ...
Cervical cancer stem cell-associated genes: Prognostic implications in cervical cancer (Review).
(Oncology Letters, 2019-03-18)
Cervical cancer is the fourth most common type of gynecological malignancy to affect females, worldwide. Although high-risk human papillomavirus (HR-HPV) infection is the primary etiologic agent associated with the development ...
MMP-2 salivary activity in type 2 diabetes mellitus patients
(Diabetology & Metabolic Syndrome, 2019-01)
Type 2 diabetes mellitus (T2DM) and periodontitis are chronic inflammatory diseases with a bidirec¿ tional relationship. The uncontrolled levels of glucose in T2DM patients change the pathophysiology and balance of ...