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Overexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia.
(ONCOLOGY LETTERS, 2017-08-23)
Dihydrofolate reductase (DHFR) has an important function in DNA synthesis and is a target of methotrexate, which is a crucial treatment option for acute lymphoblastic leukemia (ALL). However, the number of studies conducted ...