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vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
(Medical Microbiology, 2017-11-30)
Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is ...
The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional Profile In Vivo
(BioMed Research International, 2017-10-10)
Influence of serum leptin levels and Q223R leptin receptor polymorphism on clinical characteristic of patients with rheumatoid arthritis from Western Mexico.
(eJIFCC, 2018-11)
The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico.
PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
(Journal Clinical Laboratory Analysis, 2018-10-14)
Background: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40 CD154 interaction promotes pro¿inflammatory cytokines secretion and autoantibodies production. PTPN22 gene ...
La leptina promueve la expresión de Hic-5 y la formación de puntos de actina por la vía dependiente de FAK-Src en células epiteliales mamarias MCF10A.
(Biomédica, 2019-01-01)
Leptin is a hormone secreted by adipocytes that has been associated with the epithelial-mesenchymal transition (EMT). Additionally, leptin promotes the migration and invasion of mammary epithelial cells through the activation ...
KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico.
(Hindawi, 2019-01-06)
Systemic Sclerosis (SSc) is an autoimmune, inflammatory, and multisystemic disease characterized by the presence of autoantibodies and fibrosis. The pathogenesis involves the interaction between immune system cells such ...
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
(ELSEVIER, 2019-05)
Polymorphisms in folate-related genes are closely related to the development of cancer. The 5,10-MTHFR 677C>T and RFC1 80G>A polymorphisms are associated with an increased risk of susceptibility to pediatric ALL.
Terminal Deoxynucleotidyl Transferase in type B Acute Lymphoblastic Leukemia.
(Avens Publishing, 2019-02)
Terminal deoxynucleotidyl transferase (TdT or DNTT) is a nuclear enzyme whose expression is restricted to normal tissue (thymus and bone marrow) and to lymphoid precursors of the B and T cell. TdT catalyzes the addition ...
New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.
(FebsPress, 2019-04-18)
Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators of gene expression that control oncogenic pathways to modulate the radiotherapy ...
Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells.
(Cancer Cell International, 2019-01)
Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic agent in ...