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PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
(Journal Clinical Laboratory Analysis, 2018-10-14)
Background: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40 CD154 interaction promotes pro¿inflammatory cytokines secretion and autoantibodies production. PTPN22 gene ...