Expression of IL-33 in subjects with periodontitis: a systematic review and meta-analysis

Abstract

Periodontitis is an oral infection characterized by the destruction of the soft and hard tissues that support the teeth. This disease is associated with the presence of a polymicrobial dysbiotic film constituted by a high prevalence of periodontopathogens (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Tannerella forsythia, Porphyromonas gingivalis and Treponema denticola) and regulated in turn by immunoinflammatory factors. Its high incidence worldwide is worrying and alarming because it is one of the leading causes of tooth loss, making it a major public health problem that remains unresolved. Both the diagnosis and treatment of periodontitis are well established, however, there are still gaps in knowledge about the molecular mechanisms involved in the regulation of the inflammatory and destructive process of the periodontium, therefore, knowing these aspects will greatly facilitate scientists and clinicians in precision treatment.