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PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.

dc.contributor.authorRuiz Noa, Yeniley
dc.contributor.authorHernandez Bello, Jorge
dc.contributor.authorLlamas Covarrubias, Mara Anais
dc.contributor.authorPalafox Sanchez, Claudia Azucena
dc.contributor.authorOregon Romero, Edith
dc.contributor.authorSánchez Hernández, Pedro Ernesto
dc.contributor.authorRamirez Dueñas, Maria Guadalupe
dc.contributor.authorParra Rojas, Isela
dc.contributor.authorMuñoz Valle, Jose Francisco
dc.creatorRUIZ NOA, YENILEY; 345231
dc.creatorHERNANDEZ BELLO, JORGE; 513697
dc.creatorLLAMAS COVARRUBIAS, MARA ANAIS; 256915
dc.creatorPALAFOX SANCHEZ, CLAUDIA AZUCENA; 202977
dc.creatorOREGON ROMERO, EDITH; 123093
dc.creatorSánchez Hernández, Pedro Ernesto; 38809
dc.creatorRAMIREZ DUEÑAS, MARIA GUADALUPE; 202714
dc.creatorPARRA ROJAS, ISELA; 39755
dc.creatorMuñoz Valle, Jose Francisco; 25759
dc.date.accessioned2020-04-14T16:54:11Z
dc.date.available2020-04-14T16:54:11Z
dc.date.issued2018-10-14
dc.identifier.issnhttps://doi.org/10.1002/jcla.22710
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/1186
dc.description.abstractBackground: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40 CD154 interaction promotes pro¿inflammatory cytokines secretion and autoantibodies production. PTPN22 gene encodes LYP protein, an inhibitor of T¿ and B¿cell activation. PTPN22 1858C>T polymorphism confers rheumatoid arthritis (RA) susceptibility. Hence, we evaluate the relationship between 1858C>T polymorphism with CD40 and CD154 expression and IFN secretion in RA patients.
dc.formatpdf
dc.language.isospa
dc.publisherJournal Clinical Laboratory Analysis
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectrheumatoid
dc.subjectarthritis
dc.subjectanti¿CCP
dc.subject.classificationBIOLOGÍA Y QUÍMICA::CIENCIAS DE LA VIDA::OTRAS ESPECIALIDADES DE LA BIOLOGÍA
dc.titlePTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator2||24||2499
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineBiología y Química
dc.identifier.cvuagro7412


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