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PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
dc.contributor.author | Ruiz Noa, Yeniley | |
dc.contributor.author | Hernandez Bello, Jorge | |
dc.contributor.author | Llamas Covarrubias, Mara Anais | |
dc.contributor.author | Palafox Sanchez, Claudia Azucena | |
dc.contributor.author | Oregon Romero, Edith | |
dc.contributor.author | Sánchez Hernández, Pedro Ernesto | |
dc.contributor.author | Ramirez Dueñas, Maria Guadalupe | |
dc.contributor.author | Parra Rojas, Isela | |
dc.contributor.author | Muñoz Valle, Jose Francisco | |
dc.creator | RUIZ NOA, YENILEY; 345231 | |
dc.creator | HERNANDEZ BELLO, JORGE; 513697 | |
dc.creator | LLAMAS COVARRUBIAS, MARA ANAIS; 256915 | |
dc.creator | PALAFOX SANCHEZ, CLAUDIA AZUCENA; 202977 | |
dc.creator | OREGON ROMERO, EDITH; 123093 | |
dc.creator | Sánchez Hernández, Pedro Ernesto; 38809 | |
dc.creator | RAMIREZ DUEÑAS, MARIA GUADALUPE; 202714 | |
dc.creator | PARRA ROJAS, ISELA; 39755 | |
dc.creator | Muñoz Valle, Jose Francisco; 25759 | |
dc.date.accessioned | 2020-04-14T16:54:11Z | |
dc.date.available | 2020-04-14T16:54:11Z | |
dc.date.issued | 2018-10-14 | |
dc.identifier.issn | https://doi.org/10.1002/jcla.22710 | |
dc.identifier.uri | http://ri.uagro.mx/handle/uagro/1186 | |
dc.description.abstract | Background: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40 CD154 interaction promotes pro¿inflammatory cytokines secretion and autoantibodies production. PTPN22 gene encodes LYP protein, an inhibitor of T¿ and B¿cell activation. PTPN22 1858C>T polymorphism confers rheumatoid arthritis (RA) susceptibility. Hence, we evaluate the relationship between 1858C>T polymorphism with CD40 and CD154 expression and IFN secretion in RA patients. | |
dc.format | ||
dc.language.iso | spa | |
dc.publisher | Journal Clinical Laboratory Analysis | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | rheumatoid | |
dc.subject | arthritis | |
dc.subject | anti¿CCP | |
dc.subject.classification | BIOLOGÍA Y QUÍMICA::CIENCIAS DE LA VIDA::OTRAS ESPECIALIDADES DE LA BIOLOGÍA | |
dc.title | PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients. | |
dc.type | Artículo | |
dc.type.conacyt | article | |
dc.rights.acces | openAccess | |
dc.audience | generalPublic | |
dc.identificator | 2||24||2499 | |
dc.format.digitalOrigin | Born digital | |
dc.thesis.degreelevel | Doctorado | |
dc.thesis.degreename | Doctorado en Ciencias Biomédicas | |
dc.thesis.degreedepartment | Facultad de Ciencias Químico Biológicas | |
dc.thesis.degreediscipline | Biología y Química | |
dc.identifier.cvuagro | 7412 |
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