vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
Abstract
Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes in strains from patients with different types of chronic gastritis; (iii) to characterize the variable region of cagA alleles.
Abstract
Helicobacter pylori is a Gram-negative bacterium that colonizes the gastrointestinal tract of humans, mainly the gastric mucosa. These bacteria colonize around half of the world¿s population, although their prevalence varies among geographical regions within a country, as well as between rural and urban areas, due to the socio-economic conditions, age and population ethnicity [1, 2]. Even though 80% of the infected population is asymptomatic, persistent infection by these bacteria causes chronic inflammation of the mucosa, which manifests as gastritis that can develop to chronic atrophic gastritis, intestinal metaplasia, dysplasia, and finally, gastric cancer [3¿5].
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