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dc.contributor.authorOrganista Nava, Jorge
dc.contributor.authorGomez Gomez, Yazmin
dc.contributor.authorIllades_Aguiar, Berenice
dc.contributor.authorRivera Ramirez, Ana Bertha
dc.contributor.authorSaavedra Herrera, Monica Virginia
dc.contributor.authorLeyva Vazquez, Marco Antonio
dc.creatorORGANISTA NAVA, JORGE; 236745
dc.creatorGOMEZ GOMEZ, YAZMIN; 236728
dc.creatorIllades_Aguiar, Berenice;#0000-0003-3937-335X
dc.creatorRIVERA RAMIREZ, ANA BERTHA; 900512
dc.creatorSAAVEDRA HERRERA, MONICA VIRGINIA;*CA277352
dc.creatorLEYVA VAZQUEZ, MARCO ANTONIO; 264272
dc.date.accessioned2020-04-14T16:53:13Z
dc.date.available2020-04-14T16:53:13Z
dc.date.issued2017-08-23
dc.identifier.issnDOI: 10.3892/ol.2018.842
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/1184
dc.description.abstractDihydrofolate reductase (DHFR) has an important function in DNA synthesis and is a target of methotrexate, which is a crucial treatment option for acute lymphoblastic leukemia (ALL). However, the number of studies conducted to date on DHFR expression in childhood ALL is limited. The aim of the present study was to determine whether the expression of DHFR is associated with survival in childhood ALL. The expression of DHFR in 96 children with ALL and 100 control individuals was determined using reverse transcription-quantitative polymerase chain reaction. The results of the present study demonstrated that the expression of DHFR mRNA in children with ALL was significantly increased (P<0.001), compared with that in the control group. In addition, increased levels of DHFR mRNA were observed in patients with B-cell lineage, compared with patients with T-cell lineage ALL (P<0.05). The Kaplan-Meier estimator analysis revealed that children with ALL who exhibited increased levels of DHFR mRNA had a decreased overall survival time (P<0.05). It was observed that certain patient prognostic features (including age, sex, white blood cell count and high DHFR expression), are associated with poor survival (log-rank test, P<0.05). Therefore, the results of the present study indicated that DHFR upregulation is a factor for poor survival in ALL.
dc.formatpdf
dc.language.isospa
dc.publisherONCOLOGY LETTERS
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectdihydrofolate
dc.subjectreductase
dc.subjectacute
dc.subjectlymphoblastic
dc.subjectleukemia
dc.subject.classificationBIOLOGÍA Y QUÍMICA::CIENCIAS DE LA VIDA::OTRAS ESPECIALIDADES DE LA BIOLOGÍA
dc.titleOverexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia.
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator2||24||2499
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineBiología y Química
dc.identifier.cvuagro2025


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