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dc.contributor.authorAréchaga Ocampo, Elena
dc.contributor.authorLopez Camarillo, Mario Cesar
dc.contributor.authorVillegas Sepulveda, Nicolas
dc.contributor.authorGonzalez De La Rosa, Claudia Haydee
dc.contributor.authorPerez Añorve, Isidro Xavier
dc.contributor.authorRoldan Perez, Reynalda
dc.contributor.authorFlores Perez, Jose Ali
dc.contributor.authorPeña Curiel, Omar
dc.contributor.authorAngeles Zaragoza, Oscar
dc.contributor.authorRangel Corona, Rosalva
dc.contributor.authorGonzalez Barrios, Juan Antonio
dc.contributor.authorBonilla Moreno, Raúl
dc.contributor.authorDel Moral Hernandez, Oscar
dc.contributor.authorHerrera, Luis A
dc.contributor.authorGarcia Carranca, Alejandro Manuel
dc.creatorAréchaga Ocampo, Elena; 40111
dc.creatorLOPEZ CAMARILLO, MARIO CESAR; 31322
dc.creatorVILLEGAS SEPULVEDA, NICOLAS; 13386
dc.creatorGONZALEZ DE LA ROSA, CLAUDIA HAYDEE; 40114
dc.creatorPEREZ AÑORVE, ISIDRO XAVIER; 416929
dc.creatorROLDAN PEREZ, REYNALDA; 628970
dc.creatorFLORES PEREZ, JOSE ALI; 330771
dc.creatorPEÑA CURIEL, OMAR; 869512
dc.creatorRANGEL CORONA, ROSALVA; 120247
dc.creatorGONZALEZ BARRIOS, JUAN ANTONIO; 122257
dc.creatorDEL MORAL HERNANDEZ, OSCAR; 47380
dc.creatorGARCIA CARRANCA, ALEJANDRO MANUEL; 7859
dc.date.accessioned2020-04-17T02:03:54Z
dc.date.available2020-04-17T02:03:54Z
dc.date.issued2017-03
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/1202
dc.description.abstractRadiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance is a biological behavior of cancer cells that limits the efficacy of this treatment. Deregulation of microRNAs contributes to the molecular mechanism underlying resistance to radiotherapy in cancer cells. Although the functional roles of microRNAs have been well described in lung cancer, their functional roles in radioresistance are largely unclear. In this study, we established a non-small cell lung carcinoma Calu-1 radioresistant cell line by continuous exposure to therapeutic doses of ionizing radiation as a model to investigate radioresistance-associated microRNAs.
dc.description.sponsorshipThe authors are grateful to Biologist Samuel Aréchaga for conducting statistical analyses and to undergraduate students Perla López, Mauricio Orozco, Liliana Nava, and Erick Valdés for their collaboration in producing experimental data. The authors also thank M.S. Christian Adame (Centro Medico Nacional ¿Siglo XXI,¿ México) for optimizing the radiotherapy dose for all experimental analyses. EAO is very grateful to Dr. Greco Hernández (Instituto Nacional de Cancerología, México) for his valuable critical comments about this project.
dc.formatpdf
dc.language.isoeng
dc.publisherTumor Biology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectMicroRNAs
dc.subjectradioresistance
dc.subjectradiotherapy
dc.subjectlung cancer
dc.subjectbiomarkers
dc.subject.classificationBIOLOGÍA Y QUÍMICA::CIENCIAS DE LA VIDA::BIOQUÍMICA
dc.titleTumor suppressor miR-29c regulates radioresistance in lung cancer cells
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator2||24||2403
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineBIOLOGÍA Y QUÍMICA
dc.identifier.cvuagro15158


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