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dc.contributor.authorMartinez Jimenez, Luis Antonio
dc.contributor.authorOrganista Nava, Jorge
dc.contributor.authorIllades_Aguiar, Berenice
dc.contributor.authorLeyva Vazquez, Marco Antonio
dc.contributor.authorGomez Gomez, Yazmin
dc.creatorMARTINEZ JIMENEZ, LUIS ANTONIO; 440860
dc.creatorORGANISTA NAVA, JORGE; 236745
dc.creatorIllades_Aguiar, Berenice;#0000-0003-3937-335X
dc.creatorLEYVA VAZQUEZ, MARCO ANTONIO; 264272
dc.creatorGOMEZ GOMEZ, YAZMIN; 236728
dc.date.accessioned2020-04-21T23:31:59Z
dc.date.available2020-04-21T23:31:59Z
dc.date.issued2019-02
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/1223
dc.description.abstractTerminal deoxynucleotidyl transferase (TdT or DNTT) is a nuclear enzyme whose expression is restricted to normal tissue (thymus and bone marrow) and to lymphoid precursors of the B and T cell. TdT catalyzes the addition of deoxynucleotides independently of the template in the 3¿-terminal hydroxyl end of the oligonucleotide primers. In addition, it plays a crucial role in the insertion of N regions during the rearrangement of immunoglobulin genes and receptor T and B cells (TCR and BCR) at the DJ binding sites and variable (V) diversity (D) binding (J). This mechanism of the diversity of the binding is essential for the development of a repertoire of immunoglobulin¿s and B and T cell receptors.
dc.formatpdf
dc.language.isospa
dc.publisherAvens Publishing
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectTerminal deoxynucleotidyl
dc.subjecttransferase
dc.subjectrearrangement of immunoglobulin
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
dc.titleTerminal Deoxynucleotidyl Transferase in type B Acute Lymphoblastic Leukemia.
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||3299
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro11126486


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