Expresión de p16ink4a en lesiones premalignas de bajo grado con infección por Virus del Papiloma Humano
Arreola Castro, Yuliana Paulina
MetadataShow full item record
Background. The protein p16INK4a is an inhibitor of cyclin-dependent kinases (CDKs) that slows the cell cycle by inactivating CDKs involved in the phosphorylation of the retinoblastoma protein (pRb). Infection with high-risk human papillomavirus (HPV-HR) is a risk factor for the progression of squamous intraepithelial lesions (SIL) of the uterine cervix. It has been described that the overexpression of p16INK4a is induced by the presence of HPV-HR E7 oncoprotein, and has been suggested that p16INK4a is a potential marker of the SIL.
- Tesis