Polimorfismos en el gen de la Dihidrofolato Reductasa y respuesta al Metotrexato en Leucemia Linfoblástica aguda en México
Gómez Gómez, Yazmin
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The presence of polymorphisms in regulatory regions causes increased expression of dihydrofolate reductase (DHFR), and it is associated with methotrexate (MTX) treatment adverse events. A case control study was conducted on 70 children with acute lymphoblastic leukemia (ALL) and 140 children without disease.
Acute lymphoblastic leukemia (ALL) is a hematologic neoplasia characterized by clonal proliferation of immature lymphoid cells, the result of the malignant transformation of a lymphoid progenitor cell. In Mexico, acute leukemia is considering a problem of public health, it represents the fourth position of mortality of all neoplasic malignancies in children younger than fifteen years. In 2005, leukemia was the second cause of mortality in state of Guerrero in children younger than fifteen years, according to Institute National of Statistics Geography and Computing.
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