Polimorfismos de la dnmt3b y su asociación con el desarrollo de lesiones precancerosas y cáncer cérvico uterino
García Aguilar, Rubén
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Epigenetic and genetic factors are important for the development of cervical cancer (CC). DNMT3B plays a crucial role in carcinogenesis, its novo metilase activity can lead to silencing of tumor suppressor genes. Polymorphic variants in the gene for DNMT3B can influence their activity, thus modulating the susceptibility to CC. Aim. To determine the frequency of polymorphisms A204S, E368K, -579G>T and 46359C>T of DNMT3B and its association with development of low and high grade squamous intraepithelial lesions (LGSIL-HGSIL) and CC.
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