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dc.contributor.authorVega Peña, Arianna
dc.contributor.authorIllades_Aguiar, Berenice
dc.contributor.authorFlores Alfaro, Eugenia
dc.contributor.authorLeyva Vazquez, Marco Antonio
dc.contributor.authorCastañeda Saucedo, Eduardo
dc.contributor.authorAlarcón Romero, Luz Del Carmen
dc.creatorVega Peña, Arianna; 237448
dc.creatorIllades_Aguiar, Berenice;#0000-0003-3937-335X
dc.creatorFlores Alfaro, Eugenia; 224947
dc.creatorLeyva Vazquez, Marco Antonio; 264272
dc.creatorCastañeda Saucedo, Eduardo; 83639
dc.creatorAlarcón Romero, Luz Del Carmen; 259901
dc.date.accessioned2019-04-04T00:01:59Z
dc.date.available2019-04-04T00:01:59Z
dc.date.issued2015-09-04
dc.identifier.issn0970-9371
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/395
dc.description.abstractLow-grade squamous intraepithelial lesions (LSIL) are the earliest lesions of the uterine cervix, the persistence and integration of high-risk human papillomavirus (HR-HPV) as type 16, which promotes the development of more aggressive lesions. Aim: To select more aggressive lesions with tendency to progress to invasive cervical cancer. Materials and Methods: A total of 75 cytological specimens in liquid base (Liqui-PREP) were analyzed: 25 specimens were with no signs of SIL (NSIL) and without HPV; 25 NSIL with HPV-16, and 25 with both LSIL and HPV-16. The expression of Ki-67, telomerase, and viral E6 was evaluated by immunocytochemistry; and the detection of viral DNA was done by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLPs) for genotyping or sequencing of HPV-16. The physical state of HPV-16 was evaluated by in situ hybridization with amplification with tyramide.
dc.description.sponsorshipThe authors thank the Consejo Nacional de Ciencia y Tecnología (CONACyT, Mexico) for scholarships granted in the period 2011-2013.
dc.formatpdf
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4
dc.subjectCAB Thesaurus /Cervical lesions
dc.subjectCAB Thesaurus/ Human papilloma virus
dc.subjectCAB Thesaurus /Integration
dc.subjectCAB Thesaurus /Telomerase
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::BIOLOGÍA HUMANA
dc.titleRisk of progression of early cervical lesions is associated with Integration and persistence of HPV-16 and expression of E6, Ki-67, and telomerase)
dc.typeArtículo
dc.contributor.committeeMemberLópez Bayghen, Esther
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||2410
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro10054794
dc.identifier.doihttps://doi.org/10.4103/0970-9371.126644


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