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dc.contributor.authorVillanueva Duque, José Alfredo
dc.contributor.authorZúñiga Eulogio, Miriam Daniela
dc.contributor.authorDena Beltran, José Luis
dc.contributor.authorCastañeda Saucedo, Eduardo
dc.contributor.authorCalixto Galvez, Mercedes
dc.contributor.authorMendoza Catalán, Miguel Ángel
dc.contributor.authorOrtuño Pineda, Carlos
dc.contributor.authorNavarro Tito, Napoleon
dc.creatorVillanueva Duque, José Alfredo; 368328
dc.creatorZúñiga Eulogio, Miriam Daniela; 857962
dc.creatorDena Beltran, José Luis; 856829
dc.creatorCastañeda Saucedo, Eduardo; 83639
dc.creatorCalixto Galvez, Mercedes; 173695
dc.creatorMendoza Catalán, Miguel Ángel; 236704
dc.creatorOrtuño Pineda, Carlos; 162572
dc.creatorNavarro Tito, Napoleon; 175113
dc.date.accessioned2019-04-04T00:02:00Z
dc.date.available2019-04-04T00:02:00Z
dc.date.issued2017-10-15
dc.identifier.issn1936-2625
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/396
dc.description.abstractEpithelial-mesenchymal transition (EMT) is a biological process involved in different steps of tumor progression and metastasis of breast cancer cells. Epidemiological studies suggest a link between obesity and the progression of breast cancer. Leptin is an adipocyte-secreted hormone which can promote cell migration and invasión as part of EMT in breast cancer cells. We investigated the effect of leptin on expression of EMT markers in MCF10A cells, as well as, the role of FAK and ERK in this process. We found that leptin induces morphological changes from an epithelial phenotype towards a mesenchymal phenotype and promotes cell migration in MCF10A cells. Moreover, leptin induces an increase in vimentin expression, changes in the cellular localization of E-cadherin and increase in FAK and ERK phosphorylation.
dc.description.sponsorshipThis work was supported by a grant from SEPCONACYT CB-2014-01-239870. A. V-D was supported by a CONACYT predoctoral training grant
dc.formatpdf
dc.language.isoeng
dc.publisherClin Exp Pathol
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4
dc.subjectCAB Thesaurus /Leptin
dc.subjectCAB Thesaurus /Cell migration
dc.subjectCAB Thesaurus /Breast cancer
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::BIOLOGÍA HUMANA::PROTEÍNAS
dc.titleLeptin induces partial epithelial-mesenchymal transition in a FAK-ERK dependent pathway in MCF10A mammary non-tumorigenic cells
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||2410||230227
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro10124253


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