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dc.contributor.authorJiménez Wences, Hilda
dc.contributor.authorPeralta Zaragoza, Oscar
dc.contributor.authorFernandez Tilapa, Gloria
dc.creatorJiménez Wences, Hilda; 170212
dc.creatorPeralta Zaragoza, Oscar; 122021
dc.creatorFernandez Tilapa, Gloria; 90223
dc.date.accessioned2019-04-04T00:02:00Z
dc.date.available2019-04-04T00:02:00Z
dc.date.issued2014-03-13
dc.identifier.issn2467-2476
dc.identifier.urihttp://ri.uagro.mx/handle/uagro/398
dc.description.abstractCancer is a complex disease caused by genetic and epigenetic abnormalities that affect gene expression. The progression from precursor lesions to invasive cervical cancer is influenced by persistent human papilloma virus (HPV) infection, which induces changes in the host genome and epigenome. Epigenetic alterations, such as aberrant miRNA expression and changes in DNA methylation status, favor the expression of oncogenes and the silencing of tumor-suppressor genes. Given that some miRNA genes can be regulated through epigenetic mechanisms, it has been proposed that alterations in the methylation status of miRNA promoters could be the driving mechanism behind their aberrant expression in cervical cancer. For these reasons, we assessed the relationship among HPV infection, cellular DNA methylation and miRNA expression. We conclude that alterations in the methylation status of protein-coding genes and various miRNA genes are influenced by HPV infection, the viral genotype, the physical state of the viral DNA, and viral oncogenic risk. Furthermore, HPV induces deregulation of miRNA expression, particularly at loci near fragile sites. This deregulation occurs through the E6 and E7 proteins, which target miRNA transcription factors such as p53.
dc.description.sponsorshipThe translation of the present study to the English language was financed by the Programa de Fortalecimiento Académico del Posgrado de Alta Calidad, key, I010/455/2013 C-677/2013
dc.formatpdf
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4
dc.subjectCAB Thesaurus /Methylation
dc.subjectCAB Thesaurus /Human papilloma virus
dc.subjectCAB Thesaurus /Cervical cancer
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::PATOLOGÍA::CARCINOGÉNESIS
dc.titleHuman papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)
dc.typeArtículo
dc.type.conacytarticle
dc.rights.accesopenAccess
dc.audiencegeneralPublic
dc.identificator3||32||3207||320703
dc.format.digitalOriginBorn digital
dc.thesis.degreelevelDoctorado
dc.thesis.degreenameDoctorado en Ciencias Biomédicas
dc.thesis.degreegrantorUniversidad Autónoma de Guerrero
dc.thesis.degreedepartmentFacultad de Ciencias Químico Biológicas
dc.thesis.degreedisciplineMedicina y Ciencias de la Salud
dc.identifier.cvuagro11201867
dc.identifier.doihttps://doi.org/10.3892/or.2014.3142


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4