Changes in global gene expression profiles induced by HPV16 E6 oncoprote invariants incervical carcinoma C33-Acells

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2015-12-02
Autor
Zacapala Gómez, Ana Elvira
Del Moral Hernández, Oscar
Leyva Vazquez, Marco Antonio
Illades_Aguiar, Berenice
Alarcón Romero, Luz Del Carmen
Hidalgo Miranda, Alfredo
Romero Cordoba, Sandra Lorena
Beltrán Anaya
Fredy Omar
Villegas Sepúlveda, Nicolás
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Resumen
We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E-Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-Acells. Affymetrix GeneChip human Transcriptome Array 2.0 platform was used to analyze the expression of over 245,000 coding transcripts. We found that HPV16 E6 variant saltered the expression of 387 different genes in comparison withE-Prototype
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http://ri.uagro.mx/handle/uagro/404
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http://creativecommons.org/licenses/by-nc-nd/4
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc-nd/4