Efecto de las variantes de la oncoproteína E6 del VPH16 en la apoptosis inducida por cisplatino
Javier González, Dorian Estefany
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Several studies have been carried out that have analyzed the oncogenic potential of some variants of HPV16 and the deregulation of apoptosis. Demonstrating that the variants of the E6 oncoprotein of HPV16 and the E6 prototype sensitize NIKS to apoptosis induced by the extrinsic pathway. Or that the variants differentially deregulate the expression of pro and anti-apoptotic genes. Objective: Therefore, in this work we evaluated the ability of the E6 variants of HPV16 to promote the resistance to apoptosis induced by cisplatin in C33-A cells.
- Tesis