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Metilación del gen L1 e integración de VPH-AR en citología normal, lesiones precancerosas y CaCU y efecto de E6 en la metilación de genes relacionados a cáncer
(Universidad Autónoma de Guerrero (México), 2017-01)
Cervical cancer (CaCU) is the third most common neoplasm among women, whose causative agent is the human papillomavirus (HPV). HPV 16 and 18 are most frequently associated with this malignancy. Viral integration is a ...
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation
(American Journal of Cancer Research, 2017-01)
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair ...
Methylation of the L1 gene and integration of human papillomavirus 16 and 18 in cervical carcinoma and premalignant lesions
(Oncology Letters, 2017-09-13)
High-risk human papillomavirus (HPV) is the primary cause of cervical carcinoma (CC). Viral integration into the host chromosomes is associated with neoplastic progression, and epigenetic changes may occur as a result. The ...