DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation
Peralta Arrieta, Irlanda
Hernández Sotelo, Daniel
Castro Coronel, Yaneth
Leyva Vázquez, Marco Antonio
Illades Aguiar, Berenice
MetadataShow full item record
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B. We found that the overexpression of DNMT3B in HaCaT cells, modulate the expression of genes related to cancer, downregulated the expression of 151 genes with CpG islands and downregulated the expression of the VAV3 gene via methylation of its promoter. These results highlight the importance of DNMT3B in gene expression and human cancer
- Artículos 
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4
Showing items related by title, author, creator and subject.
Gold, Silver, and Copper phytoextraction by helianthus annuus sunflower grown on mine tailings amended with plant growth regulators and cyanide Rubio Carrasco, Werner; Toribio Jiménez, Jeiry (African journal of microbiology research, 2014)Phytoextraction has been suggested as aviable technique for gold recovery from some areas of mine tailings and mineralized soils. Plant Growht Regulators have been used due to their potential to improve rates of metal ...
Niveles de expresión, metilación y polimorfismos en el gen de leptina en madres-neonatos como determinantes del peso al nacer Marino Ortega, Linda Anahí (Universidad Autónoma de Guerrero (México), 2015-10)
Little environmental dimension, gives reason to an urgent need and sustainable proposal of curricular inclusion Bedolla Solano, Ramón; Sampedro Rosas, María Laura (IJRDO-Journal of Educational Research, 2017)The environmental crisis in the world, has promoted the integration of the environmental dimension in education, in this area, are located universities. Resolutions of international summits such as the one organized by the ...