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Polimorfismos del gen MIF (-794CATT5-8 y -173G>C) en pacientes con esclerosis sistémica: asociación con la expresión de MIF-CD74 y la respuesta Th1/Th2/Th17
(Universidad Autónoma de Guerrero (México), 2019-03)
The macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with proinflammatory functions that seems to be involved in the pathogenesis of systemic sclerosis (SSc). The role of MIF polymorphisms, its ...
Estudio de variantes del número de copias en genes candidato asociados a obesidad infantil
(Universidad Autónoma de Guerrero (México), 2017-02)
Obesity is one of the major health problems in the world, in Mexico the combined prevalence of overweight and obesity in school-age children is 34.4%. The weight gain starts during childhood, in its origin, environmental ...
Resistencia a la insulina inducida por exposición a metamidofos: participación del estrés oxidativo
(Universidad Autónoma de Guerrero (México), 2018-01)
Insulin resistance (IR) is the incapacity observed in tissues for responding to biological activity induce by insulin stimulation; this condition has been linked with the development of several chronic diseases. The causes ...
Differential proteins among normal cérvix cells and cervical cancer cells with HPV-16 infection, through mass spectrometrybased Proteomics (2D-DIGE) in women from Southern México
(Proteome Science, 2016-09-05)
Cervical cancer (CC) is the fourth most common cancer in women worldwide with an estimated 528,000 new cases in 2012. The same year México had an incidence of 13,960 and a mortality of 4769 cases. There are several diagnosis ...
Risk of progression of early cervical lesions is associated with Integration and persistence of HPV-16 and expression of E6, Ki-67, and telomerase)
(2015-09-04)
Low-grade squamous intraepithelial lesions (LSIL) are the earliest lesions of the uterine cervix, the persistence and integration of high-risk human papillomavirus (HR-HPV) as type 16, which promotes the development of ...
MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cells
(International Journal of Clinical and Experimental Medicine, 2015-09-30)
MicroRNAs are involved in diverse biological processes through regulation of gene expression. The microRNA profile has been shown to be altered in cervical cancer (CC). MiR-16-1 belongs to the miR-16 cluster and has been ...
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation
(American Journal of Cancer Research, 2017-01)
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair ...
Changes in global gene expression profiles induced by HPV16 E6 oncoprote invariants incervical carcinoma C33-Acells
(Virology, 2015-12-02)
We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E-Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned ...
Methylation of the L1 gene and integration of human papillomavirus 16 and 18 in cervical carcinoma and premalignant lesions
(Oncology Letters, 2017-09-13)
High-risk human papillomavirus (HPV) is the primary cause of cervical carcinoma (CC). Viral integration into the host chromosomes is associated with neoplastic progression, and epigenetic changes may occur as a result. The ...
miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer
(Infectious Agents and Cancer, 2015-01)
The aberrant expression of miR-23b is involved in the development and progression of cancer. The aim of this study was to evaluate the potential role of methylation in the silencing of miR-23b in cervical cancer celllines ...