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DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation
(American Journal of Cancer Research, 2017-01)
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair ...
Methylation of the L1 gene and integration of human papillomavirus 16 and 18 in cervical carcinoma and premalignant lesions
(Oncology Letters, 2017-09-13)
High-risk human papillomavirus (HPV) is the primary cause of cervical carcinoma (CC). Viral integration into the host chromosomes is associated with neoplastic progression, and epigenetic changes may occur as a result. The ...
Efecto de la sobre-expresión de DNMT3B en la actividad transcripcional de genes relacionados con el cáncer
(Tlamati, 2017-06-30)
Abnormal methylation of promoters of genes suppressors of tumor and repairers of DNA is an epigenetic process that leads to its transcriptional silencing and is also a common event observed in cancer. DNMT3B is a DNA ...
Metilación del gen l1 del VPH-16 como marcador de cáncer cervical
(Tlamati, 2017-06-30)
A total of 14 infection-positive samples were processed only for HPV-16, of which 5 were cytologically diagnosed as normal cytology (CN), 6 as a low-grade squamous intraepithelial lesion (LEIBG) and 3 cancer samples. The ...